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Structure of sumoylated PCNA

Analyse Structure of sumoylated PCNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3PGE
Type: protein
Length: 335 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sumo-modified proliferating cell nuclear antigen; Proliferating cell nuclear antigen
UniProt: Q12306, P15873
Pockets: 3 · best druggability 0.32

Structure

x-ray diffraction · 2 distinct chains · 18% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sumo-modified proliferating cell nuclear antigen	protein	172	16% helix, 41% strand	Q12306, P15873
B	Proliferating cell nuclear antigen	protein	163	20% helix, 44% strand	P15873

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	88	0.32	0.73	24	empty
2	55	0.31	0.76	14	empty
3	58	0.28	0.73	15	empty

Interfaces

1 interface between chains.

A–B · 2983 Å² buried · 58 hydrogen bonds · protein-protein

Compared structures

3PGE · Structure of sumoylated PCNA · the same entry in another collection · chain A against A, TM-score 1.00
Q12306 · AlphaFold monomer V2.0 prediction for ubiquitin-like protein SMT3 (Q12306) · a predicted model of the same protein · chain A against A, TM-score 0.44

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q12306
Every structure of UniProt P15873
Elsewhere: RCSB PDB 3PGE · PDBe 3PGE · UniProt Q12306 · UniProt P15873

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