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Human adipocyte lipid-binding protein FABP4 in complex with 3-(4- methoxy-3-methylphenyl) propionic acid

Analyse Human adipocyte lipid-binding protein FABP4 in complex with 3-(4… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3P6D
Type: protein
Length: 139 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fatty acid-binding protein, adipocyte
UniProt: P15090
Ligands: ZGB
Pockets: 1 · best druggability 0.85

Structure

x-ray diffraction · 1 distinct chain · 16% helix, 55% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fatty acid-binding protein, adipocyte	protein	139	16% helix, 55% strand	P15090

Ligands and binding sites

ZGB · 3-(4-methoxy-3-methylphenyl)propanoic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	270	0.85	0.96	33	ZGB

Compared structures

3P6D · Human adipocyte lipid-binding protein FABP4 in complex with 3-(4-methoxy-3-methylphenyl)… · the same entry in another collection · chain A against A, TM-score 1.00
P15090 · AlphaFold monomer V2.0 prediction for fatty acid-binding protein, adipocyte (P15090) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P15090
Elsewhere: RCSB PDB 3P6D · PDBe 3P6D · UniProt P15090

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