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Structure of fascin

Analyse Structure of fascin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3P53
Type: protein
Length: 970 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fascin
UniProt: Q16658
Pockets: 11 · best druggability 0.73

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fascin	protein	486	7% helix, 48% strand	Q16658
B	Fascin	protein	484	7% helix, 48% strand	Q16658

Ligands and binding sites

GOL · Glycerol · additive · 8 copies · chains A, B
1PE · Pentaethylene glycol · additive · 5 copies · chains A, B
12P · Dodecaethylene glycol · additive · chains A
PG0 · 2-(2-methoxyethoxy)ethanol · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	619	0.73	0.80	44	GOL
2	386	0.66	0.80	61	1PE, PG0
3	512	0.66	0.78	67	1PE
4	164	0.49	0.77	27	empty
5	94	0.45	0.80	18	empty

Interfaces

1 interface between chains.

A–B · 592 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

3P53 · Structure of fascin · the same entry in another collection · chain A against A, TM-score 1.00
Q16658 · AlphaFold monomer V2.0 prediction for fascin (Q16658) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q16658
Elsewhere: RCSB PDB 3P53 · PDBe 3P53 · UniProt Q16658

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