Structure of an amyloid forming peptide klvffa from amyloid beta in complex with orange G

Structure

x-ray diffraction · 1 distinct chain · 0% helix, 67% strand (DSSP).

Ligands and binding sites

• ORA · 7-hydroxy-8-[(E)-phenyldiazenyl]naphthalene-1,3-disulfonic acid · ligand · 2 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

5 interfaces between chains.

• A–B · 288 Ų buried · 7 hydrogen bonds · protein-protein
• C–D · 286 Ų buried · 8 hydrogen bonds · protein-protein
• B–C · 86 Ų buried · 1 hydrogen bond · protein-protein
• A–D · 28 Ų buried · 0 hydrogen bonds · protein-protein
• A–C · 21 Ų buried · 0 hydrogen bonds · protein-protein

Compared structures

• 3OVJ · Structure of an amyloid forming peptide KLVFFA from amyloid beta in complex with orange G · the same entry in another collection · chain D against D, TM-score 1.00
• P05067 · AlphaFold monomer V2.0 prediction for amyloid-beta precursor protein (P05067) · a predicted model of the same protein · chain A against A, TM-score 0.81

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P05067
• Elsewhere: RCSB PDB 3OVJ · PDBe 3OVJ · UniProt P05067