Research workbench
Structure of beta-catenin with lef-1
Analyse Structure of beta-catenin with lef-1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3OUW
- Type
- protein
- Length
- 524 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Catenin beta-1; Lymphoid enhancer-binding factor 1
- UniProt
- Q02248, P27782
- Pockets
- 2 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 67% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Catenin beta-1 | protein | 496 | 69% helix, 0% strand | Q02248 |
| B | Lymphoid enhancer-binding factor 1 | protein | 28 | 29% helix, 0% strand | P27782 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 343 | 0.69 | 0.82 | 39 | empty |
| 2 | 108 | 0.66 | 0.90 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1480 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 3OUW · Structure of beta-catenin with Lef-1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q02248 · AlphaFold monomer V2.0 prediction for catenin beta-1 (Q02248) · a predicted model of the same protein · chain A against A, TM-score 0.97
- P27782 · AlphaFold monomer V2.0 prediction for lymphoid enhancer-binding factor 1 (P27782) · a predicted model of the same protein · chain B against A, TM-score 0.25
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q02248
- Every structure of UniProt P27782
- Elsewhere: RCSB PDB 3OUW · PDBe 3OUW · UniProt Q02248 · UniProt P27782
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