Research workbench
X-ray structure of the N-terminal fha domain from S. cerevisiae RAD53P in complex with a phosphothreonine peptide at 1.6 a resolution
Analyse X-ray structure of the N-terminal fha domain from S. cerevisiae RAD53P in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1G6G
- Type
- protein
- Length
- 271 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein kinase RAD53; Ser-leu-glu-val-tpo-glu-ala-aspala-thr-phe-ala- lys
- EC
- 2.7.1.-
- UniProt
- P22216
- Pockets
- 2 · best druggability 0.44
Structure
x-ray diffraction · 4 distinct chains · 11% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein kinase RAD53 (EC 2.7.1.-) | protein | 127 | 12% helix, 38% strand | P22216 |
| B | Protein kinase RAD53 (EC 2.7.1.-) | protein | 124 | 11% helix, 38% strand | P22216 |
| E | Ser-leu-glu-val-tpo-glu-ala-aspala-thr-phe-ala- lys | protein | 8 | 0% helix, 0% strand | — |
| F | Ser-leu-glu-val-tpo-glu-ala-aspala-thr-phe-ala- lys | protein | 12 | 0% helix, 0% strand | — |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 150 | 0.44 | 0.76 | 21 | empty |
| 2 | 85 | 0.32 | 0.73 | 18 | empty |
Interfaces
3 interfaces between chains.
- B–F · 494 Ų buried · 14 hydrogen bonds · protein-protein
- A–E · 473 Ų buried · 17 hydrogen bonds · protein-protein
- A–B · 288 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 1G6G · X-ray structure of the N-terminal fha domain from S. cerevisiae RAD53P in complex with a… · the same entry in another collection · chain A against A, TM-score 1.00
- P22216 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase RAD53 (P22216) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22216
- Elsewhere: RCSB PDB 1G6G · PDBe 1G6G · UniProt P22216
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.