UniProt P22216
Serine/threonine-protein kinase RAD53 (P22216)
Serine/threonine-protein kinase RAD53 (UniProt P22216), EC 2.7.12.1: 49 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 18 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P22216
- Protein
- Serine/threonine-protein kinase RAD53
- EC
- 2.7.12.1
- Experimental structures
- 49
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 18 · 2 records with a druggable one
Structures
50 records of P22216 in the MolNFT archive: 49 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DMZ | A refined NMR structure of a new phophopeptide-binding domain containing the FHA2 of RAD53 | solution nmr | A | — | — |
| 1DMZ | A refined NMR structure of a new phophopeptide-binding domain containing the FHA2 of RAD53 | solution nmr | A | — | — |
| 1FHQ | Refined solution structure of the FHA2 domain of RAD53 | solution nmr | A | — | — |
| 1FHQ | Refined solution structure of the FHA2 domain of RAD53 | solution nmr | A | — | — |
| 1FHR | Solution structure of the FHA2 domain of RAD53 complexed with a phosphotyrosyl peptide | solution nmr | A | — | — |
| 1FHR | Solution structure of the FHA2 domain of RAD53 complexed with a phosphotyrosyl peptide | solution nmr | A | — | — |
| 1G3G | NMR structure of the FHA1 domain of yeast RAD53 | solution nmr | A | — | — |
| 1G3G | NMR structure of the FHA1 domain of yeast RAD53 | solution nmr | A | — | — |
| 1G6G | X-ray structure of the N-terminal fha domain from S. cerevisiae RAD53P in complex with a… | x-ray diffraction | A, B | — | — |
| 1G6G | X-ray structure of the N-terminal fha domain from S. cerevisiae RAD53P in complex with a… | x-ray diffraction | A, B | — | — |
| 1J4K | Solution structure of the FHA2 domain of RAD53 complexed with a phosphotyrosyl peptide derived from… | solution nmr | A | — | — |
| 1J4K | Solution structure of the FHA2 domain of RAD53 complexed with a phosphotyrosyl peptide derived from… | solution nmr | A | — | — |
| 1J4L | Solution structure of the FHA2 domain of RAD53 complexed with a phosphothreonyl peptide derived… | solution nmr | A | — | — |
| 1J4L | Solution structure of the FHA2 domain of RAD53 complexed with a phosphothreonyl peptide derived… | solution nmr | A | — | — |
| 1J4O | Refined NMR structure of the FHA1 domain of yeast RAD53 | solution nmr | A | — | — |
| 1J4O | Refined NMR structure of the FHA1 domain of yeast RAD53 | solution nmr | A | — | — |
| 1J4P | NMR structure of the FHA1 domain of RAD53 in complex with a RAD9-derived phosphothreonine (at T155)… | solution nmr | A | — | — |
| 1J4P | NMR structure of the FHA1 domain of RAD53 in complex with a RAD9- derived phosphothreonine (at… | solution nmr | A | — | — |
| 1J4Q | NMR structure of the FHA1 domain of RAD53 in complex with a RAD9-derived phosphothreonine (at T192)… | solution nmr | A | — | — |
| 1J4Q | NMR structure of the FHA1 domain of RAD53 in complex with a RAD9- derived phosphothreonine (at… | solution nmr | A | — | — |
| 1K2M | Solution Structure of the FHA2 Domain of Rad53 Complexed with a Phosphotyrosyl Peptide Derived from… | solution nmr | A | — | — |
| 1K2M | Solution structure of the FHA2 domain of RAD53 complexed with a phosphotyrosyl peptide derived from… | solution nmr | A | — | — |
| 1K2N | Solution Structure of the FHA2 domain of Rad53 Complexed with a Phosphothreonyl Peptide Derived… | solution nmr | A | — | — |
| 1K2N | Solution structure of the FHA2 domain of RAD53 complexed with a phosphothreonyl peptide derived… | solution nmr | A | — | — |
| 1K3J | Refined NMR Structure of the FHA1 Domain of Yeast Rad53 | solution nmr | A | — | — |
| 1K3J | Refined NMR structure of the FHA1 domain of yeast RAD53 | solution nmr | A | — | — |
| 1K3N | NMR Structure of the FHA1 Domain of Rad53 in Complex with a Rad9-derived Phosphothreonine (at T155)… | solution nmr | A | — | — |
| 1K3N | NMR structure of the FHA1 domain of RAD53 in complex with a RAD9- derived phosphothreonine (at… | solution nmr | A | — | — |
| 1K3Q | NMR structure of the FHA1 Domain of Rad53 in Complex with a Rad9-derived Phosphothreonine (at T192)… | solution nmr | A | — | — |
| 1K3Q | NMR structure of the FHA1 domain of RAD53 in complex with a RAD9- derived phosphothreonine (at… | solution nmr | A | — | — |
| 1QU5 | NMR structure of a new phosphotyrosine binding domain containing the FHA2 domain of rad 53 | solution nmr | A | — | — |
| 1QU5 | NMR structure of a new phosphotyrosine binding domain containing the FHA2 domain of rad 53 | solution nmr | A | — | — |
| 2A0T | NMR structure of the FHA1 domain of Rad53 in complex with a biological relevant phosphopeptide… | solution nmr | A | — | — |
| 2A0T | NMR structure of the FHA1 domain of RAD53 in complex with a biological relevant phosphopeptide… | solution nmr | A | — | — |
| 2JQI | NMR Structure of the Rad53 FHA1 domain in complex with a phosphothreonien peptide derived from… | solution nmr | A, B | — | — |
| 2JQI | NMR structure of the RAD53 FHA1 domain in complex with a phosphothreonien peptide derived from… | solution nmr | A, B | — | — |
| 2JQL | NMR structure of the yeast Dun1 FHA domain in complex with a doubly phosphorylated (pT) peptide… | solution nmr | B | — | — |
| 2JQL | NMR structure of the yeast DUN1 fha domain in complex with a doubly phosphorylated (pt) peptide… | solution nmr | B | — | — |
| 2YGV | Conserved N-terminal domain of the yeast Histone Chaperone Asf1 in complex with the C-terminal… | x-ray diffraction | E, F, G, H | — | — |
| 2YGV | Conserved N-terminal domain of the yeast histone chaperone ASF1 in complex with the C-terminal… | x-ray diffraction | E, F, G, H | — | — |
| 4PDP | Crystal structure of Rad53 kinase domain and SCD2 | x-ray diffraction | A, B | — | — |
| 4PDP | Crystal structure of RAD53 kinase domain and SCD2 | x-ray diffraction | A, B | — | — |
| 4PDS | Crystal structure of Rad53 kinase domain and SCD2 in complex with AMPPNP | x-ray diffraction | A, B | — | — |
| 4PDS | Crystal structure of RAD53 kinase domain and SCD2 in complex with amppnp | x-ray diffraction | A, B | — | — |
| 5T2F | Structure of the FHA1 domain of RAD53 bound to the brct domain of DBF4 | x-ray diffraction | A, B, C, D | — | — |
| 5T2S | Structure of the FHA1 domain of RAD53 bound simultaneously to the brct domain of DBF4 and a… | x-ray diffraction | A, C | — | — |
| 5XZV | Crystal structure of Rad53 1-466 in complex with AMP-PNP | x-ray diffraction | A, B | ANP | 9 (best 0.76) |
| 5XZV | Crystal structure of RAD53 1-466 in complex with AMP-pnp | x-ray diffraction | A, B | ANP | — |
| 5XZW | Crystal structure of RAD53 1-466 | x-ray diffraction | A, B | — | — |
| P22216 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase RAD53 (P22216) | predicted | A | — | 9 (best 0.75) |
Ligands
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 2 records
Experiment against prediction
- 1G6G chain B against the predicted model P22216: TM-score 0.99, RMSD 0.46 Å
- 1G6G chain B against the predicted model P22216: TM-score 0.99, RMSD 0.46 Å
- 4PDS chain B against the predicted model P22216: TM-score 0.97, RMSD 1.01 Å
- 4PDS chain B against the predicted model P22216: TM-score 0.97, RMSD 1.01 Å
- 4PDS chain A against the predicted model P22216: TM-score 0.97, RMSD 1.06 Å
- 4PDS chain A against the predicted model P22216: TM-score 0.97, RMSD 1.06 Å
- 4PDP chain A against the predicted model P22216: TM-score 0.97, RMSD 1.11 Å
- 4PDP chain A against the predicted model P22216: TM-score 0.97, RMSD 1.11 Å
- 4PDP chain B against the predicted model P22216: TM-score 0.97, RMSD 1.11 Å
- 4PDP chain B against the predicted model P22216: TM-score 0.97, RMSD 1.11 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.