Research workbench
Semi-synthetic ribonuclease S: meta-cyano-phenylalanine at position 8
Analyse Semi-synthetic ribonuclease S: meta-cyano-phenylalanine at position 8 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3OQZ
- Type
- protein
- Length
- 235 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribonuclease pancreatic
- EC
- 3.1.27.5
- UniProt
- P61823
- Pockets
- 1 · best druggability 0.49
Structure
x-ray diffraction · 3 distinct chains · 20% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| a, b | Ribonuclease pancreatic (EC 3.1.27.5) | protein | 15 | 60% helix, 7% strand | P61823 |
| A | Ribonuclease pancreatic (EC 3.1.27.5) | protein | 102 | 17% helix, 42% strand | P61823 |
| B | Ribonuclease pancreatic (EC 3.1.27.5) | protein | 103 | 17% helix, 42% strand | P61823 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 216 | 0.49 | 0.75 | 27 | empty |
Interfaces
3 interfaces between chains.
- b–B · 691 Ų buried · 14 hydrogen bonds · protein-protein
- a–A · 689 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 29 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide, 2 modified (disulfide, nonstandard).
Compared structures
- 3OQZ · Semi-synthetic ribonuclease S: meta-cyano-phenylalanine at position 8 · the same entry in another collection · chain a against a, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61823
- Elsewhere: RCSB PDB 3OQZ · PDBe 3OQZ · UniProt P61823
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