Research workbench
Crystal structure of importin-alpha bound to a CLIC4 nls peptide
Analyse Crystal structure of importin-alpha bound to a CLIC4 nls peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3OQS
- Type
- protein
- Length
- 432 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peptide of chloride intracellular channel protein 4; Importin subunit alpha-2
- UniProt
- Q9Y696, P52293
- Pockets
- 1 · best druggability 0.45
Structure
x-ray diffraction · 2 distinct chains · 73% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Peptide of chloride intracellular channel protein 4 | protein | 7 | 0% helix, 0% strand | Q9Y696 |
| A | Importin subunit alpha-2 | protein | 425 | 74% helix, 0% strand | P52293 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 79 | 0.45 | 0.81 | 12 | empty |
Interfaces
1 interface between chains.
- B–A · 637 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 3OQS · Crystal structure of importin-alpha bound to a CLIC4 NLS peptide · the same entry in another collection · chain B against B, TM-score 1.00
- P52293 · AlphaFold monomer V2.0 prediction for importin subunit alpha-1 (P52293) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q9Y696 · AlphaFold monomer V2.0 prediction for chloride intracellular channel protein 4 (Q9Y696) · a predicted model of the same protein · chain B against A, TM-score 0.57
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y696
- Every structure of UniProt P52293
- Elsewhere: RCSB PDB 3OQS · PDBe 3OQS · UniProt Q9Y696 · UniProt P52293
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