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Structure of the FAS/FADD death domain assembly

Analyse Structure of the FAS/FADD death domain assembly in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3OQ9
Type: protein
Length: 890 residues
Chains: 10
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tumor necrosis factor receptor superfamily member 6; Protein fadd
UniProt: P25446, Q13158
Pockets: 12 · best druggability 0.83

Structure

x-ray diffraction · 2 distinct chains · 71% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E	Tumor necrosis factor receptor superfamily member 6	protein	86	69% helix, 0% strand	P25446
H, I, J, K, L	Protein fadd	protein	92	73% helix, 0% strand	Q13158

Pockets

12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	488	0.83	0.90	70	empty
2	373	0.83	0.91	59	empty
3	484	0.82	0.89	58	empty
4	361	0.78	0.88	58	empty
5	394	0.78	0.87	60	empty

Interfaces

28 interfaces between chains.

B–C · 480 Å² buried · 6 hydrogen bonds · protein-protein
E–L · 464 Å² buried · 5 hydrogen bonds · protein-protein
C–D · 446 Å² buried · 11 hydrogen bonds · protein-protein
D–K · 423 Å² buried · 2 hydrogen bonds · protein-protein
A–B · 414 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

3OQ9 · Structure of the FAS/FADD death domain assembly · the same entry in another collection · chain L against L, TM-score 1.00
Q13158 · AlphaFold monomer V2.0 prediction for fas-associated death domain protein (Q13158) · a predicted model of the same protein · chain I against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P25446
Every structure of UniProt Q13158
Elsewhere: RCSB PDB 3OQ9 · PDBe 3OQ9 · UniProt P25446 · UniProt Q13158

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