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Crystal structure of C-terminal domain of human galectin-8
Analyse Crystal structure of C-terminal domain of human galectin-8 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3OJB
- Type
- protein
- Length
- 524 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Galectin-8
- UniProt
- O00214
- Pockets
- 5 · best druggability 0.59
Structure
x-ray diffraction · 1 distinct chain · 2% helix, 56% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Galectin-8 | protein | 131 | 2% helix, 56% strand | O00214 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 473 | 0.59 | 0.74 | 34 | empty |
| 2 | 201 | 0.54 | 0.78 | 26 | empty |
| 3 | 180 | 0.46 | 0.75 | 26 | empty |
| 4 | 97 | 0.37 | 0.75 | 18 | empty |
| 5 | 56 | 0.29 | 0.75 | 18 | empty |
Interfaces
5 interfaces between chains.
- A–B · 542 Ų buried · 5 hydrogen bonds · protein-protein
- A–D · 496 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 353 Ų buried · 7 hydrogen bonds · protein-protein
- B–D · 152 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 64 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00214
- Elsewhere: RCSB PDB 3OJB · PDBe 3OJB · UniProt O00214
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