Research workbench
Crystal structure of the linker-DH/PH domains of P115-rhogef
Analyse Crystal structure of the linker-DH/PH domains of P115-rhogef in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3ODW
- Type
- protein
- Length
- 657 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Rho guanine nucleotide exchange factor 1
- UniProt
- Q92888
- Pockets
- 7 · best druggability 0.57
Structure
x-ray diffraction · 2 distinct chains · 60% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rho guanine nucleotide exchange factor 1 | protein | 331 | 59% helix, 15% strand | Q92888 |
| B | Rho guanine nucleotide exchange factor 1 | protein | 326 | 60% helix, 13% strand | Q92888 |
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 174 | 0.57 | 0.81 | 27 | empty |
| 2 | 121 | 0.44 | 0.77 | 17 | empty |
| 3 | 73 | 0.33 | 0.75 | 10 | empty |
| 4 | 57 | 0.32 | 0.76 | 12 | empty |
| 5 | 72 | 0.31 | 0.74 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 972 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 3ODW · Crystal Structure of the Linker-DH/PH domains of p115-RhoGEF · the same entry in another collection · chain A against A, TM-score 1.00
- Q92888 · AlphaFold monomer V2.0 prediction for rho guanine nucleotide exchange factor 1 (Q92888) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92888
- Elsewhere: RCSB PDB 3ODW · PDBe 3ODW · UniProt Q92888
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