Research workbench
Structural basis of carbohydrate recognition by calreticulin
Analyse Structural basis of carbohydrate recognition by calreticulin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3O0X
- Type
- protein
- Length
- 499 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calreticulin
- UniProt
- Q3TVD2
- Ligands
- MAN, GLC, CA
- Pockets
- 2 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 16% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calreticulin | protein | 250 | 17% helix, 42% strand | Q3TVD2 |
| B | Calreticulin | protein | 249 | 15% helix, 42% strand | Q3TVD2 |
Ligands and binding sites
- MAN · alpha-D-mannopyranose · sugar · 6 copies · chains A, B
- GLC · alpha-D-glucopyranose · sugar · 2 copies · chains A, B
- CA · Calcium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 428 | 0.70 | 0.82 | 54 | empty |
| 2 | 57 | 0.35 | 0.78 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 413 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
- 3O0X · Structural basis of carbohydrate recognition by calreticulin · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q3TVD2
- Elsewhere: RCSB PDB 3O0X · PDBe 3O0X · UniProt Q3TVD2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.