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Molecular analysis of the interaction of the HDL receptor sr-bi with the adaptor protein PDZK1

Analyse Molecular analysis of the interaction of the HDL receptor sr-bi with the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3NGH
Type: protein
Length: 212 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: PDZ domain-containing protein 1
UniProt: Q9JIL4
Pockets: 2 · best druggability 0.43

Structure

x-ray diffraction · 1 distinct chain · 25% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	PDZ domain-containing protein 1	protein	106	25% helix, 27% strand	Q9JIL4

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	115	0.43	0.77	14	empty
2	109	0.41	0.76	19	empty

Interfaces

1 interface between chains.

A–B · 550 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

3NGH · Molecular Analysis of the Interaction of the HDL Receptor SR-BI with the Adaptor Protein… · the same entry in another collection · chain A against A, TM-score 1.00
Q9JIL4 · AlphaFold monomer V2.0 prediction for NA(+)/H(+) exchange regulatory cofactor nhe-RF3… · a predicted model of the same protein · chain A against A, TM-score 0.85

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9JIL4
Elsewhere: RCSB PDB 3NGH · PDBe 3NGH · UniProt Q9JIL4

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