MolNFT v1 · #264819 · protein
AlphaFold monomer V2.0 prediction for NA(+)/H(+) exchange regulatory cofactor nhe-RF3 (Q9JIL4)
Q9JIL4: “AlphaFold monomer V2.0 prediction for NA(+)/H(+) exchange regulatory cofactor nhe-RF3 (Q9JIL4)”. 8 pockets (best druggability 0.55). MolNFT v1 #264819 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q9JIL4
- Type
- protein
- Length
- 519 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x79a905d858Ce72991FD6E7a9C6498620f42E146D
- Molecule
- NA(+)/H(+) exchange regulatory cofactor nhe-RF3
- UniProt
- Q9JIL4
- Pockets
- 8 · best druggability 0.55
Structure
1 distinct chain · 24% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NA(+)/H(+) exchange regulatory cofactor nhe-RF3 | protein | 519 | 24% helix, 23% strand | Q9JIL4 |
Pockets
8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 331 | 0.55 | 0.75 | 35 | empty |
| 2 | 144 | 0.41 | 0.74 | 18 | empty |
| 3 | 74 | 0.40 | 0.79 | 13 | empty |
| 4 | 78 | 0.35 | 0.76 | 14 | empty |
| 5 | 58 | 0.31 | 0.76 | 18 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 4F8K · Molecular analysis of the interaction between the prostacyclin receptor and the first PDZ… · an experimental structure of the same protein · chain A against A, TM-score 0.21
- 4F8K · Molecular analysis of the interaction between the prostacyclin receptor and the first PDZ… · an experimental structure of the same protein · chain A against A, TM-score 0.21
- 2EDZ · Solution structures of the PDZ domain of mus musculus PDZ domain- containing protein 1 · an experimental structure of the same protein · chain A against A, TM-score 0.20
- 2EDZ · Solution structures of the PDZ domain of mus musculus PDZ domain-containing protein 1 · an experimental structure of the same protein · chain A against A, TM-score 0.20
- 3NGH · Molecular Analysis of the Interaction of the HDL Receptor SR-BI with the Adaptor Protein… · an experimental structure of the same protein · chain A against A, TM-score 0.19
- 3NGH · Molecular analysis of the interaction of the HDL receptor sr-bi with the adaptor protein… · an experimental structure of the same protein · chain A against A, TM-score 0.19
- 2D90 · Solution structure of the third PDZ domain of PDZ domain containing protein 1 · an experimental structure of the same protein · chain A against A, TM-score 0.16
- 2D90 · Solution structure of the third PDZ domain of PDZ domain containing protein 1 · an experimental structure of the same protein · chain A against A, TM-score 0.16
- 3R68 · Molecular Analysis of the PDZ3 domain of PDZK1 · an experimental structure of the same protein · chain A against A, TM-score 0.16
- 3R68 · Molecular analysis of the PDZ3 domain of PDZK1 · an experimental structure of the same protein · chain A against A, TM-score 0.16
- 4R2Z · Molecular analysis of the PDZ4 domain of mouse PDZK1 · an experimental structure of the same protein · chain A against A, TM-score 0.16
- 4R2Z · Molecular Analysis of the PDZ4 Domain of Mouse PDZK1 · an experimental structure of the same protein · chain A against A, TM-score 0.16
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9JIL4
- Elsewhere: UniProt Q9JIL4 · AlphaFold DB Q9JIL4
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