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Substrate binding domain of the human heat shock 70KDA protein 9 (mortalin)

Analyse Substrate binding domain of the human heat shock 70KDA protein 9 (mortalin) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3N8E
Type: protein
Length: 318 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Stress-70 protein, mitochondrial
UniProt: P38646
Pockets: 4 · best druggability 0.50

Structure

x-ray diffraction · 1 distinct chain · 24% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Stress-70 protein, mitochondrial	protein	159	24% helix, 35% strand	P38646

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	203	0.50	0.76	24	empty
2	118	0.46	0.78	22	empty
3	152	0.46	0.77	23	empty
4	92	0.38	0.76	14	empty

Interfaces

1 interface between chains.

A–B · 470 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

3N8E · Substrate binding domain of the human Heat Shock 70kDa protein 9 (mortalin) · the same entry in another collection · chain A against A, TM-score 1.00
P38646 · AlphaFold monomer V2.0 prediction for stress-70 protein, mitochondrial (P38646) · a predicted model of the same protein · chain A against A, TM-score 0.69

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P38646
Elsewhere: RCSB PDB 3N8E · PDBe 3N8E · UniProt P38646

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