Research workbench
Il-1 receptor type 1 complexed with antagonist peptide AF10847
Analyse Il-1 receptor type 1 complexed with antagonist peptide AF10847 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1G0Y
- Type
- protein
- Length
- 331 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interleukin-1 receptor, type I; Antagonist peptide AF10847
- UniProt
- P14778
- Pockets
- 4 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| R | Interleukin-1 receptor, type I | protein | 310 | 3% helix, 43% strand | P14778 |
| I | Antagonist peptide AF10847 | protein | 21 | 33% helix, 10% strand | — |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 810 | 0.75 | 0.79 | 67 | empty |
| 2 | 227 | 0.58 | 0.80 | 37 | empty |
| 3 | 95 | 0.55 | 0.85 | 31 | empty |
| 4 | 62 | 0.29 | 0.74 | 16 | empty |
Interfaces
1 interface between chains.
- R–I · 1312 Ų buried · 22 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 1G0Y · Il-1 receptor type 1 complexed with antagonist peptide AF10847 · the same entry in another collection · chain R against R, TM-score 1.00
- P14778 · AlphaFold monomer V2.0 prediction for interleukin-1 receptor type 1 (P14778) · a predicted model of the same protein · chain R against A, TM-score 0.61
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14778
- Elsewhere: RCSB PDB 1G0Y · PDBe 1G0Y · UniProt P14778
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