Research workbench
Structure of the tropomyosin overlap complex from chicken smooth muscle
Analyse Structure of the tropomyosin overlap complex from chicken smooth muscle in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3MUD
- Type
- protein
- Length
- 434 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA repair protein XRCC4,TROPOMYOSIN alpha-1 chain; Tropomyosin alpha-1…
- UniProt
- Q13426, P04268, P09493, Q15691
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.40
Structure
x-ray diffraction · 4 distinct chains · 55% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA repair protein XRCC4,TROPOMYOSIN alpha-1 chain | protein | 173 | 45% helix, 33% strand | Q13426, P04268 |
| B | DNA repair protein XRCC4,TROPOMYOSIN alpha-1 chain | protein | 172 | 45% helix, 31% strand | Q13426, P04268 |
| C | Tropomyosin alpha-1 CHAIN,MICROTUBULE-associated protein RP/EB family member 1 | protein | 41 | 95% helix, 0% strand | P09493, Q15691 |
| D | Tropomyosin alpha-1 CHAIN,MICROTUBULE-associated protein RP/EB family member 1 | protein | 48 | 94% helix, 0% strand | P09493, Q15691 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 93 | 0.40 | 0.77 | 17 | empty |
| 2 | 81 | 0.37 | 0.77 | 14 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1662 Ų buried · 9 hydrogen bonds · protein-protein
- C–D · 956 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 348 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 341 Ų buried · 1 hydrogen bond · protein-protein
- B–D · 277 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 3MUD · Structure of the Tropomyosin Overlap Complex from Chicken Smooth Muscle · the same entry in another collection · chain B against B, TM-score 1.00
- Q13426 · AlphaFold monomer V2.0 prediction for DNA repair protein XRCC4 (Q13426) · a predicted model of the same protein · chain B against A, TM-score 0.96
- P09493 · AlphaFold monomer V2.0 prediction for tropomyosin alpha-1 chain (P09493) · a predicted model of the same protein · chain C against A, TM-score 0.93
- Q15691 · AlphaFold monomer V2.0 prediction for microtubule-associated protein RP/EB family member… · a predicted model of the same protein · chain C against A, TM-score 0.81
- P04268 · AlphaFold monomer V2.0 prediction for tropomyosin alpha-1 chain (P04268) · a predicted model of the same protein · chain B against A, TM-score 0.32
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13426
- Every structure of UniProt P04268
- Every structure of UniProt P09493
- Every structure of UniProt Q15691
- Elsewhere: RCSB PDB 3MUD · PDBe 3MUD · UniProt Q13426 · UniProt P04268 · UniProt P09493 · UniProt Q15691
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