Research workbench
Chromo domain of human histone-lysine N-methyltransferase SUV39H1
Analyse Chromo domain of human histone-lysine N-methyltransferase SUV39H1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3MTS
- Type
- protein
- Length
- 181 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone-lysine N-methyltransferase SUV39H1
- EC
- 2.1.1.43
- UniProt
- O43463
- Pockets
- 2 · best druggability 0.65
Structure
x-ray diffraction · 3 distinct chains · 41% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone-lysine N-methyltransferase SUV39H1 (EC 2.1.1.43) | protein | 62 | 44% helix, 32% strand | O43463 |
| B | Histone-lysine N-methyltransferase SUV39H1 (EC 2.1.1.43) | protein | 61 | 39% helix, 36% strand | O43463 |
| C | Histone-lysine N-methyltransferase SUV39H1 (EC 2.1.1.43) | protein | 58 | 40% helix, 38% strand | O43463 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 458 | 0.65 | 0.77 | 36 | empty |
| 2 | 75 | 0.28 | 0.72 | 15 | empty |
Interfaces
3 interfaces between chains.
- B–C · 991 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 537 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 57 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3MTS · Chromo Domain of Human Histone-Lysine N-Methyltransferase SUV39H1 · the same entry in another collection · chain A against A, TM-score 1.00
- O43463 · AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase SUV39H1 (O43463) · a predicted model of the same protein · chain C against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43463
- Elsewhere: RCSB PDB 3MTS · PDBe 3MTS · UniProt O43463
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