MolNFT v1 · #442395 · protein
AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase SUV39H1 (O43463)
O43463: “AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase SUV39H1 (O43463)”. 5 pockets (best druggability 0.72). MolNFT v1 #442395 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O43463
- Type
- protein
- Length
- 412 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x54E712e282c590D9A20961451A63f1380e0a3dD4
- Molecule
- Histone-lysine N-methyltransferase SUV39H1
- UniProt
- O43463
- Pockets
- 5 · best druggability 0.72
Structure
1 distinct chain · 23% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone-lysine N-methyltransferase SUV39H1 | protein | 412 | 23% helix, 22% strand | O43463 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 757 | 0.72 | 0.78 | 71 | empty |
| 2 | 267 | 0.56 | 0.77 | 32 | empty |
| 3 | 92 | 0.54 | 0.84 | 16 | empty |
| 4 | 77 | 0.39 | 0.78 | 16 | empty |
| 5 | 100 | 0.39 | 0.76 | 19 | empty |
Compared structures
- 3MTS · Chromo domain of human histone-lysine N-methyltransferase SUV39H1 · an experimental structure of the same protein · chain A against B, TM-score 0.14
- 3MTS · Chromo Domain of Human Histone-Lysine N-Methyltransferase SUV39H1 · an experimental structure of the same protein · chain A against B, TM-score 0.14
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43463
- Elsewhere: UniProt O43463 · AlphaFold DB O43463
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