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AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase SUV39H1 (O43463)

Analyse AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

Accession: O43463
Type: protein
Length: 412 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x54E712e282c590D9A20961451A63f1380e0a3dD4
Molecule: Histone-lysine N-methyltransferase SUV39H1
UniProt: O43463
Pockets: 5 · best druggability 0.72

Structure

1 distinct chain · 23% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Histone-lysine N-methyltransferase SUV39H1	protein	412	23% helix, 22% strand	O43463

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	757	0.72	0.78	71	empty
2	267	0.56	0.77	32	empty
3	92	0.54	0.84	16	empty
4	77	0.39	0.78	16	empty
5	100	0.39	0.76	19	empty

Compared structures

3MTS · Chromo domain of human histone-lysine N-methyltransferase SUV39H1 · an experimental structure of the same protein · chain A against B, TM-score 0.14
3MTS · Chromo Domain of Human Histone-Lysine N-Methyltransferase SUV39H1 · an experimental structure of the same protein · chain A against B, TM-score 0.14

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O43463
Elsewhere: UniProt O43463 · AlphaFold DB O43463

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