Research workbench
X-ray crystallographic studies on hexameric insulins in the presence of helix-stabilizing agents, thiocyanate, methylparaben and phenol
Analyse X-ray crystallographic studies on hexameric insulins in the presence of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3MTH
- Type
- protein
- Length
- 100 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Methylparaben insulin
- UniProt
- P01315
- Ligands
- MPB, ZN, CL
Structure
x-ray diffraction · 3 distinct chains · 59% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Methylparaben insulin | protein | 21 | 62% helix, 5% strand | P01315 |
| B | Methylparaben insulin | protein | 28 | 68% helix, 11% strand | P01315 |
| D | Methylparaben insulin | protein | 30 | 50% helix, 10% strand | P01315 |
Ligands and binding sites
- MPB · 4-hydroxy-benzoic acid methyl ester · ligand · chains A, B
- ZN · Zinc ion · metal · 2 copies · chains B, D
- CL · Chloride ion · ion · 2 copies · chains B, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
5 interfaces between chains.
- C–D · 841 Ų buried · 11 hydrogen bonds · protein-protein
- B–D · 728 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 564 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 69 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 35 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 3MTH · X-ray crystallographic studies on hexameric insulins in the presence of helix-stabilizing… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01315
- Elsewhere: RCSB PDB 3MTH · PDBe 3MTH · UniProt P01315
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