Research workbench

Human early B-cell factor 1 (EBF1) IPT/TIG domain

Analyse Human early B-cell factor 1 (EBF1) IPT/TIG domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3MQI
Type: protein
Length: 269 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcription factor COE1
UniProt: Q9UH73
Ligands: EMC, TMO
Pockets: 1 · best druggability 0.59

Structure

x-ray diffraction · 2 distinct chains · 0% helix, 56% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Transcription factor COE1	protein	90	0% helix, 56% strand	Q9UH73
C	Transcription factor COE1	protein	89	0% helix, 56% strand	Q9UH73

Ligands and binding sites

EMC · Ethyl mercury ion · ligand · 6 copies · chains A, B, C
TMO · trimethylamine oxide · ligand · chains B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	260	0.59	0.79	45	empty

Interfaces

3 interfaces between chains.

A–B · 598 Å² buried · 3 hydrogen bonds · protein-protein
B–C · 447 Å² buried · 2 hydrogen bonds · protein-protein
A–C · 289 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

3MQI · Human early B-cell factor 1 (EBF1) IPT/TIG domain · the same entry in another collection · chain A against A, TM-score 1.00
Q9UH73 · AlphaFold monomer V2.0 prediction for transcription factor COE1 (Q9UH73) · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UH73
Elsewhere: RCSB PDB 3MQI · PDBe 3MQI · UniProt Q9UH73

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