Research workbench
Crystal structure of myosin-2 motor domain in complex with ADP- metavanadate and blebbistatin
Analyse Crystal structure of myosin-2 motor domain in complex with ADP- metavanadate… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3MJX
- Type
- protein
- Length
- 690 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin-2 heavy chain
- UniProt
- P08799
- Ligands
- AD9, BIT, MG
- Pockets
- 7 · best druggability 0.80
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myosin-2 heavy chain | protein | 690 | 47% helix, 16% strand | P08799 |
Ligands and binding sites
- AD9 · Adp metavanadate · ligand · chains A
- BIT · (-)-1-phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-B]-7-methylquinolin-4-one · ligand · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1049 | 0.80 | 0.81 | 96 | BIT |
| 2 | 446 | 0.64 | 0.78 | 53 | AD9, MG |
| 3 | 329 | 0.58 | 0.76 | 29 | empty |
| 4 | 79 | 0.43 | 0.80 | 16 | empty |
| 5 | 65 | 0.37 | 0.78 | 15 | empty |
Compared structures
- 3MJX · Crystal structure of myosin-2 motor domain in complex with ADP-Metavanadate and… · the same entry in another collection · chain A against A, TM-score 1.00
- P08799 · AlphaFold monomer V2.0 prediction for myosin-2 heavy chain (P08799) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08799
- Elsewhere: RCSB PDB 3MJX · PDBe 3MJX · UniProt P08799
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.