Research workbench
Htra proteases are activated by a conserved mechanism that can be triggered by distinct molecular cues
Analyse Htra proteases are activated by a conserved mechanism that can be triggered by… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3MH4
- Type
- protein
- Length
- 684 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protease do
- EC
- 3.4.21.-
- UniProt
- P0C0V0
- Pockets
- 10 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 14% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protease do (EC 3.4.21.-) | protein | 301 | 14% helix, 36% strand | P0C0V0 |
| B | Protease do (EC 3.4.21.-) | protein | 383 | 15% helix, 36% strand | P0C0V0 |
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 136 | 0.73 | 0.92 | 26 | empty |
| 2 | 336 | 0.67 | 0.81 | 47 | empty |
| 3 | 51 | 0.67 | 0.96 | 26 | empty |
| 4 | 109 | 0.57 | 0.85 | 27 | empty |
| 5 | 211 | 0.55 | 0.78 | 29 | empty |
Interfaces
1 interface between chains.
- A–B · 530 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 3MH4 · HtrA proteases are activated by a conserved mechanism that can be triggered by distinct… · the same entry in another collection · chain A against A, TM-score 1.00
- P0C0V0 · AlphaFold monomer V2.0 prediction for periplasmic serine endoprotease degp (P0C0V0) · a predicted model of the same protein · chain A against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0C0V0
- Elsewhere: RCSB PDB 3MH4 · PDBe 3MH4 · UniProt P0C0V0
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.