UniProt P0C0V0
Periplasmic serine endoprotease DegP (P0C0V0)
Periplasmic serine endoprotease DegP (UniProt P0C0V0), EC 3.4.21.107: 31 experimental structures and 1 predicted model on GenesisL1, 92 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0C0V0
- Protein
- Periplasmic serine endoprotease DegP
- EC
- 3.4.21.107
- Experimental structures
- 31
- Predicted models
- 1
- Pockets
- 92 · 7 records with a druggable one
Structures
32 records of P0C0V0 in the MolNFT archive: 31 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1KY9 | Crystal Structure of DegP (HtrA) | x-ray diffraction | A, B | — | — |
| 1KY9 | Crystal structure of degp (htra) | x-ray diffraction | A, B | — | — |
| 2ZLE | Cryo-EM structure of DegP12/OMP | electron microscopy | A, B, C, E, F, G, H, I, J, K, L, M | — | — |
| 2ZLE | Cryo-EM structure of DEGP12/OMP | electron microscopy | A, B, C, E, F, G, H, I, J, K, L, M | — | — |
| 3CS0 | Crystal structure of DegP24 | x-ray diffraction | A | — | — |
| 3CS0 | Crystal structure of DEGP24 | x-ray diffraction | A | — | — |
| 3MH4 | HtrA proteases are activated by a conserved mechanism that can be triggered by distinct molecular… | x-ray diffraction | A, B | — | — |
| 3MH4 | Htra proteases are activated by a conserved mechanism that can be triggered by distinct molecular… | x-ray diffraction | A, B | — | — |
| 3MH5 | HtrA proteases are activated by a conserved mechanism that can be triggered by distinct molecular… | x-ray diffraction | A, B | — | — |
| 3MH5 | Htra proteases are activated by a conserved mechanism that can be triggered by distinct molecular… | x-ray diffraction | A, B | — | — |
| 3MH6 | HtrA proteases are activated by a conserved mechanism that can be triggered by distinct molecular… | x-ray diffraction | A | — | — |
| 3MH6 | Htra proteases are activated by a conserved mechanism that can be triggered by distinct molecular… | x-ray diffraction | A | — | — |
| 3MH7 | HtrA proteases are activated by a conserved mechanism that can be triggered by distinct molecular… | x-ray diffraction | A | — | — |
| 3MH7 | Htra proteases are activated by a conserved mechanism that can be triggered by distinct molecular… | x-ray diffraction | A | — | — |
| 3OTP | Crystal structure of the DegP dodecamer with a model substrate | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3OTP | Crystal structure of the degp dodecamer with a model substrate | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3OU0 | re-refined 3CS0 | x-ray diffraction | A | — | — |
| 3OU0 | Re-refined 3CS0 | x-ray diffraction | A | — | — |
| 4A8D | DegP dodecamer with bound OMP | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 4A8D | Degp dodecamer with bound omp | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 6JJK | Crystal structure of the DegP dodecamer with a modulator | x-ray diffraction | A, B, C, D, E, F | — | 20 (best 0.77) |
| 6JJK | Crystal structure of the degp dodecamer with a modulator | x-ray diffraction | A, B, C, D, E, F | — | — |
| 6JJL | Crystal structure of the DegP dodecamer with a modulator | x-ray diffraction | A, B, C, D, E, F | — | — |
| 6JJL | Crystal structure of the degp dodecamer with a modulator | x-ray diffraction | A, B, C, D, E, F | — | — |
| 6JJO | Crystal structure of the degp dodecamer with a modulator | x-ray diffraction | A, B, C, D, E, F | — | — |
| 8F0A | Client-bound structure of a DegP trimer within a 12mer cage | electron microscopy | A, B, C, D, E, F | — | 16 (best 0.78) |
| 8F0U | Structure of a 12mer DegP cage bound to the client protein hTRF1 | electron microscopy | A, D | — | 5 (best 0.54) |
| 8F1T | Structure of an 18mer DegP cage bound to the client protein hTRF1 | electron microscopy | A, B, C, D, E, F | — | 15 (best 0.80) |
| 8F1U | Structure of a 24mer DegP cage bound to the client protein hTRF1 | electron microscopy | A, B, C, D, E, F | — | 16 (best 0.79) |
| 8F21 | Structure of a 30mer DegP cage bound to the client protein hTRF1 | electron microscopy | A, B, C, D, E, F | — | 15 (best 0.79) |
| 8F26 | Structure of a 60mer DegP cage bound to the client protein hTRF1 | electron microscopy | A, D | — | 5 (best 0.54) |
| P0C0V0 | AlphaFold monomer V2.0 prediction for periplasmic serine endoprotease degp (P0C0V0) | predicted | A | — | — |
Experiment against prediction
- 8F21 chain C against the predicted model P0C0V0: TM-score 0.99, RMSD 0.61 Å
- 8F1U chain C against the predicted model P0C0V0: TM-score 0.99, RMSD 0.61 Å
- 8F0U chain A against the predicted model P0C0V0: TM-score 0.99, RMSD 0.61 Å
- 8F1T chain C against the predicted model P0C0V0: TM-score 0.99, RMSD 0.61 Å
- 8F0A chain C against the predicted model P0C0V0: TM-score 0.99, RMSD 0.61 Å
- 8F0A chain B against the predicted model P0C0V0: TM-score 0.99, RMSD 0.61 Å
- 8F0A chain A against the predicted model P0C0V0: TM-score 0.99, RMSD 0.61 Å
- 8F21 chain A against the predicted model P0C0V0: TM-score 0.99, RMSD 0.61 Å
- 8F26 chain A against the predicted model P0C0V0: TM-score 0.99, RMSD 0.61 Å
- 8F1U chain A against the predicted model P0C0V0: TM-score 0.99, RMSD 0.61 Å
Elsewhere
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