Research workbench
Structural basis of galactose recognition in C-type animal lectins
Analyse Structural basis of galactose recognition in C-type animal lectins in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1AFD
- Type
- protein
- Length
- 462 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mannose-binding protein-a
- UniProt
- P19999
- Ligands
- CA, CL
- Pockets
- 4 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 32% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| 1, 2, 3 | Mannose-binding protein-a | protein | 154 | 32% helix, 23% strand | P19999 |
Ligands and binding sites
- CA · Calcium ion · metal · 8 copies · chains 1, 2, 3
- CL · Chloride ion · ion · 2 copies · chains 1, 3
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 559 | 0.62 | 0.74 | 59 | empty |
| 2 | 256 | 0.57 | 0.78 | 31 | empty |
| 3 | 261 | 0.57 | 0.77 | 33 | empty |
| 4 | 211 | 0.51 | 0.76 | 27 | empty |
Interfaces
3 interfaces between chains.
- 1–2 · 1150 Ų buried · 8 hydrogen bonds · protein-protein
- 1–3 · 1128 Ų buried · 8 hydrogen bonds · protein-protein
- 2–3 · 1092 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 1AFD · Structural basis of galactose recognition in C-type animal lectins · the same entry in another collection · chain 1 against 1, TM-score 1.00
- P19999 · AlphaFold monomer V2.0 prediction for mannose-binding protein a (P19999) · a predicted model of the same protein · chain 1 against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19999
- Elsewhere: RCSB PDB 1AFD · PDBe 1AFD · UniProt P19999
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