Research workbench
ETS1 complex with stromelysin-1 promoter DNA
Analyse ETS1 complex with stromelysin-1 promoter DNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3MFK
- Type
- protein + DNA
- Length
- 306 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein C-ets-1; Stromelysin-1 promoter DNA
- UniProt
- P14921
- Pockets
- 3 · best druggability 0.72
Structure
x-ray diffraction · 4 distinct chains · 47% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein C-ets-1 | protein | 138 | 49% helix, 7% strand | P14921 |
| B | Protein C-ets-1 | protein | 136 | 46% helix, 9% strand | P14921 |
| C | Stromelysin-1 promoter DNA | dna | 16 | — | — |
| D | Stromelysin-1 promoter DNA | dna | 16 | — | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 483 | 0.72 | 0.82 | 43 | empty |
| 2 | 51 | 0.33 | 0.78 | 14 | empty |
| 3 | 82 | 0.32 | 0.74 | 18 | empty |
Interfaces
6 interfaces between chains.
- C–D · 667 Ų buried · 53 hydrogen bonds · nucleic-nucleic
- A–D · 519 Ų buried · 13 hydrogen bonds · protein-nucleic
- B–C · 490 Ų buried · 11 hydrogen bonds · protein-nucleic
- A–C · 391 Ų buried · 16 hydrogen bonds · protein-nucleic
- A–B · 346 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14921
- Elsewhere: RCSB PDB 3MFK · PDBe 3MFK · UniProt P14921
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.