Research workbench
Structure of an open and closed conformation of human importin beta bound to the SNURPORTIN1 ibb-domain trapped in the same crystallographic asymmetric unit
Analyse Structure of an open and closed conformation of human importin beta bound to… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3LWW
- Type
- protein
- Length
- 1,809 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit beta-1; Snurportin-1
- UniProt
- Q14974, O95149
- Pockets
- 20 · best druggability 0.83
Structure
x-ray diffraction · 4 distinct chains · 65% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Importin subunit beta-1 | protein | 873 | 64% helix, 0% strand | Q14974 |
| B | Snurportin-1 | protein | 39 | 67% helix, 0% strand | O95149 |
| C | Importin subunit beta-1 | protein | 871 | 66% helix, 0% strand | Q14974 |
| D | Snurportin-1 | protein | 26 | 92% helix, 0% strand | O95149 |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 859 | 0.83 | 0.85 | 91 | empty |
| 2 | 101 | 0.75 | 0.95 | 29 | empty |
| 3 | 199 | 0.73 | 0.89 | 46 | empty |
| 4 | 138 | 0.65 | 0.88 | 25 | empty |
| 5 | 226 | 0.64 | 0.83 | 30 | empty |
Interfaces
4 interfaces between chains.
- A–B · 2122 Ų buried · 20 hydrogen bonds · protein-protein
- C–D · 1257 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 1221 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 27 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3LWW · Structure of an open and closed conformation of Human Importin Beta bound to the… · the same entry in another collection · chain D against D, TM-score 1.00
- Q14974 · AlphaFold monomer V2.0 prediction for importin subunit beta-1 (Q14974) · a predicted model of the same protein · chain A against A, TM-score 0.97
- O95149 · AlphaFold monomer V2.0 prediction for snurportin-1 (O95149) · a predicted model of the same protein · chain D against A, TM-score 0.84
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14974
- Every structure of UniProt O95149
- Elsewhere: RCSB PDB 3LWW · PDBe 3LWW · UniProt Q14974 · UniProt O95149
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