Research workbench
A structural model for the full-length shaker potassium channel KV1.2
Analyse A structural model for the full-length shaker potassium channel KV1.2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3LUT
- Type
- protein
- Length
- 716 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Voltage-gated potassium channel subunit beta-2; Potassium voltage-gated channel subfamily…
- UniProt
- P62483, P63142
- Ligands
- NAP, K
- Pockets
- 7 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 54% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Voltage-gated potassium channel subunit beta-2 | protein | 326 | 52% helix, 17% strand | P62483 |
| B | Potassium voltage-gated channel subfamily a member 2 | protein | 390 | 57% helix, 5% strand | P63142 |
Ligands and binding sites
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · chains A
- K · Potassium ion · metal · 6 copies · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 943 | 0.73 | 0.77 | 79 | empty |
| 2 | 342 | 0.70 | 0.83 | 60 | NAP |
| 3 | 162 | 0.49 | 0.77 | 28 | empty |
| 4 | 112 | 0.46 | 0.79 | 24 | empty |
| 5 | 126 | 0.42 | 0.76 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 398 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 3LUT · A Structural Model for the Full-length Shaker Potassium Channel Kv1.2 · the same entry in another collection · chain A against A, TM-score 1.00
- P62483 · AlphaFold monomer V2.0 prediction for voltage-gated potassium channel subunit beta-2… · a predicted model of the same protein · chain A against A, TM-score 1.00
- P63142 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily a member… · a predicted model of the same protein · chain B against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62483
- Every structure of UniProt P63142
- Elsewhere: RCSB PDB 3LUT · PDBe 3LUT · UniProt P62483 · UniProt P63142
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