UniProt P63142
Potassium voltage-gated channel subfamily A member 2 (P63142)
Potassium voltage-gated channel subfamily A member 2 (UniProt P63142): 27 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 55 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P63142
- Protein
- Potassium voltage-gated channel subfamily A member 2
- Experimental structures
- 27
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 55 · 4 records with a druggable one
Structures
28 records of P63142 in the MolNFT archive: 27 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DSX | KV1.2 T1 domain, residues 33-119, T46V mutant | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 1DSX | KV1.2 T1 domain, residues 33-119, T46V mutant | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 1QDV | N-terminal domain, voltage-gated potassium channel KV1.2 residues 33-131 | x-ray diffraction | A, B, C, D | — | — |
| 1QDV | N-terminal domain, voltage-gated potassium channel KV1.2 residues 33-131 | x-ray diffraction | A, B, C, D | — | — |
| 1QDW | N-terminal domain, voltage-gated potassium channel KV1.2 residues 33-119 | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 1QDW | N-terminal domain, voltage-gated potassium channel KV1.2 residues 33-119 | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2A79 | Mammalian Shaker Kv1.2 potassium channel- beta subunit complex | x-ray diffraction | B | — | — |
| 2A79 | Mammalian shaker KV1.2 potassium channel- beta subunit complex | x-ray diffraction | B | — | — |
| 3LNM | F233W mutant of the Kv2.1 paddle-Kv1.2 chimera channel | x-ray diffraction | B, D | — | — |
| 3LNM | F233W mutant of the KV2.1 paddle-KV1.2 chimera channel | x-ray diffraction | B, D | — | — |
| 3LUT | A Structural Model for the Full-length Shaker Potassium Channel Kv1.2 | x-ray diffraction | B | — | — |
| 3LUT | A structural model for the full-length shaker potassium channel KV1.2 | x-ray diffraction | B | — | — |
| 4JTA | Crystal structure of Kv1.2-2.1 paddle chimera channel in complex with Charybdotoxin | x-ray diffraction | B, Q | — | — |
| 4JTA | Crystal structure of KV1.2-2.1 paddle chimera channel in complex with charybdotoxin | x-ray diffraction | B, Q | — | — |
| 4JTC | Crystal structure of Kv1.2-2.1 paddle chimera channel in complex with Charybdotoxin in Cs+ | x-ray diffraction | B, H | — | — |
| 4JTC | Crystal structure of KV1.2-2.1 paddle chimera channel in complex with charybdotoxin in cs+ | x-ray diffraction | B, H | — | — |
| 4JTD | Crystal structure of Kv1.2-2.1 paddle chimera channel in complex with Lys27Met mutant of… | x-ray diffraction | B, H | — | — |
| 4JTD | Crystal structure of KV1.2-2.1 paddle chimera channel in complex with LYS27MET mutant of… | x-ray diffraction | B, H | — | — |
| 5WIE | Crystal structure of a Kv1.2-2.1 chimera K+ channel V406W mutant in an inactivated state | x-ray diffraction | B, H | PGW, K | 7 (best 0.62) |
| 5WIE | Crystal structure of a KV1.2-2.1 chimera K+ channel V406W mutant in an inactivated state | x-ray diffraction | B, H | PGW, K | — |
| 6EBK | The voltage-activated Kv1.2-2.1 paddle chimera channel in lipid nanodiscs | electron microscopy | B, D, F, H | — | — |
| 6EBK | The voltage-activated KV1.2-2.1 paddle chimera channel in lipid nanodiscs | electron microscopy | B, D, F, H | — | — |
| 6EBL | The voltage-activated Kv1.2-2.1 paddle chimera channel in lipid nanodiscs, cytosolic domain | electron microscopy | B, D, F, H | — | 12 (best 0.85) |
| 6EBL | The voltage-activated KV1.2-2.1 paddle chimera channel in lipid nanodiscs, cytosolic domain | electron microscopy | B, D, F, H | — | — |
| 6EBM | The voltage-activated KV1.2-2.1 paddle chimera channel in lipid nanodiscs, transmembrane domain of… | electron microscopy | B, D, F, H | — | — |
| 8VC6 | Voltage gated potassium ion channel Kv1.2 in Potassium | electron microscopy | A, D, B, C | — | 18 (best 0.82) |
| 8VCH | Voltage gated potassium ion channel Kv1.2 W366F, C-type inactivated | electron microscopy | A, B, C, D | K | 18 (best 0.81) |
| P63142 | AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily a member 2 (P63142) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1QDW chain A against the predicted model P63142: TM-score 0.99, RMSD 0.38 Å
- 1QDW chain A against the predicted model P63142: TM-score 0.99, RMSD 0.38 Å
- 1QDV chain A against the predicted model P63142: TM-score 0.99, RMSD 0.42 Å
- 1QDV chain A against the predicted model P63142: TM-score 0.99, RMSD 0.42 Å
- 6EBL chain B against the predicted model P63142: TM-score 0.99, RMSD 0.43 Å
- 6EBL chain B against the predicted model P63142: TM-score 0.99, RMSD 0.43 Å
- 6EBL chain D against the predicted model P63142: TM-score 0.99, RMSD 0.45 Å
- 6EBL chain H against the predicted model P63142: TM-score 0.99, RMSD 0.45 Å
- 6EBL chain F against the predicted model P63142: TM-score 0.99, RMSD 0.45 Å
- 1DSX chain A against the predicted model P63142: TM-score 0.98, RMSD 0.50 Å
Elsewhere
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