Research workbench
Crystal structure of human rig-I ctd bound to a 12 bp au rich 5' ppp dsrna
Analyse Crystal structure of human rig-I ctd bound to a 12 bp au rich 5' ppp dsrna in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3LRR
- Type
- protein + RNA
- Length
- 266 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable ATP-dependent RNA helicase DDX58; RNA…
- EC
- 3.6.1.-
- UniProt
- O95786
- Ligands
- ZN
- Pockets
- 1 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 11% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) | protein | 121 | 11% helix, 45% strand | O95786 |
| C, D | RNA (5'-R(*(ATP)P*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*U)-3') | rna | 12 | — | — |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 880 | 0.68 | 0.75 | 43 | empty |
Interfaces
5 interfaces between chains.
- C–D · 545 Ų buried · 38 hydrogen bonds · nucleic-nucleic
- B–D · 455 Ų buried · 6 hydrogen bonds · protein-nucleic
- A–C · 438 Ų buried · 7 hydrogen bonds · protein-nucleic
- A–D · 169 Ų buried · 1 hydrogen bond · protein-nucleic
- B–C · 164 Ų buried · 1 hydrogen bond · protein-nucleic
Modifications
Observed in the structure: 2 modified (nucleotide modification).
Compared structures
- 3LRR · Crystal structure of human RIG-I CTD bound to a 12 bp AU rich 5' ppp dsRNA · the same entry in another collection · chain A against A, TM-score 1.00
- O95786 · AlphaFold monomer V2.0 prediction for antiviral innate immune response receptor rig-I… · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95786
- Elsewhere: RCSB PDB 3LRR · PDBe 3LRR · UniProt O95786
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