Research workbench
Crystal structure of the HIV-1 rev dimer
Analyse Crystal structure of the HIV-1 rev dimer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3LPH
- Type
- protein
- Length
- 232 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein rev
- UniProt
- P69718
- Ligands
- BR, SO4
- Pockets
- 1 · best druggability 0.58
Structure
x-ray diffraction · 4 distinct chains · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein rev | protein | 62 | 74% helix, 0% strand | P69718 |
| B | Protein rev | protein | 55 | 76% helix, 0% strand | P69718 |
| C | Protein rev | protein | 58 | 78% helix, 0% strand | P69718 |
| D | Protein rev | protein | 57 | 74% helix, 0% strand | P69718 |
Ligands and binding sites
- BR · Bromide ion · ion · 13 copies · chains A, B, C, D
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
- MLI · Malonate ion · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 120 | 0.58 | 0.84 | 28 | BR |
Interfaces
3 interfaces between chains.
- A–B · 836 Ų buried · 6 hydrogen bonds · protein-protein
- C–D · 778 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 574 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 3LPH · Crystal structure of the HIV-1 Rev dimer · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P69718
- Elsewhere: RCSB PDB 3LPH · PDBe 3LPH · UniProt P69718
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