Research workbench
Crystal structure of capz bound to the uncapping motif from CD2AP
Analyse Crystal structure of capz bound to the uncapping motif from CD2AP in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3LK4
- Type
- protein
- Length
- 6,435 residues
- Chains
- 36
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- F-actin-capping protein subunit alpha-1; F-actin-capping protein subunit beta isoforms 1…
- UniProt
- P13127, P14315, Q9Y5K6
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · 5 distinct chains · 39% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D, G, J, M, P, S, V, Y, 1, 4, 7 | F-actin-capping protein subunit alpha-1 | protein | 269 | 40% helix, 33% strand | P13127 |
| B, E, K, Q, 2 | F-actin-capping protein subunit beta isoforms 1 and 2 | protein | 238 | 39% helix, 35% strand | P14315 |
| C, F, I, L, O, R, U, X, 0, 3, 6, 9 | CD2-associated protein | protein | 29 | 14% helix, 0% strand | Q9Y5K6 |
| H, N, W, Z, 8 | F-actin-capping protein subunit beta isoforms 1 and 2 | protein | 239 | 40% helix, 35% strand | P14315 |
| T, 5 | F-actin-capping protein subunit beta isoforms 1 and 2 | protein | 237 | 40% helix, 35% strand | P14315 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 121 | 0.80 | 0.98 | 24 | empty |
| 2 | 120 | 0.80 | 0.98 | 25 | empty |
| 3 | 120 | 0.80 | 0.98 | 23 | empty |
| 4 | 119 | 0.80 | 0.98 | 24 | empty |
| 5 | 123 | 0.80 | 0.98 | 24 | empty |
Interfaces
79 interfaces between chains.
- A–B · 3629 Ų buried · 62 hydrogen bonds · protein-protein
- 1–2 · 3625 Ų buried · 61 hydrogen bonds · protein-protein
- P–Q · 3625 Ų buried · 62 hydrogen bonds · protein-protein
- S–T · 3624 Ų buried · 60 hydrogen bonds · protein-protein
- 7–8 · 3624 Ų buried · 59 hydrogen bonds · protein-protein
Compared structures
- 3LK4 · Crystal structure of CapZ bound to the uncapping motif from CD2AP · the same entry in another collection · chain 2 against 2, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13127
- Every structure of UniProt P14315
- Every structure of UniProt Q9Y5K6
- Elsewhere: RCSB PDB 3LK4 · PDBe 3LK4 · UniProt P13127 · UniProt P14315 · UniProt Q9Y5K6
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.