Research workbench
Crystal structure of capz bound to the uncapping motif from carmil
Analyse Crystal structure of capz bound to the uncapping motif from carmil in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3LK2
- Type
- protein
- Length
- 545 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- F-actin-capping protein subunit alpha-1; F-actin-capping protein subunit beta isoforms 1…
- UniProt
- P13127, P14315, Q5VZK9
- Pockets
- 6 · best druggability 0.81
Structure
x-ray diffraction · 3 distinct chains · 37% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | F-actin-capping protein subunit alpha-1 | protein | 270 | 39% helix, 33% strand | P13127 |
| B | F-actin-capping protein subunit beta isoforms 1 and 2 | protein | 242 | 39% helix, 36% strand | P14315 |
| T | Leucine-rich repeat-containing protein 16A | protein | 33 | 12% helix, 0% strand | Q5VZK9 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 121 | 0.81 | 0.99 | 19 | empty |
| 2 | 136 | 0.63 | 0.86 | 24 | empty |
| 3 | 208 | 0.54 | 0.78 | 26 | empty |
| 4 | 138 | 0.45 | 0.77 | 19 | empty |
| 5 | 126 | 0.41 | 0.76 | 18 | empty |
Interfaces
3 interfaces between chains.
- A–B · 3457 Ų buried · 47 hydrogen bonds · protein-protein
- B–T · 1493 Ų buried · 27 hydrogen bonds · protein-protein
- A–T · 767 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 3LK2 · Crystal structure of CapZ bound to the uncapping motif from CARMIL · the same entry in another collection · chain A against A, TM-score 1.00
- P14315 · AlphaFold monomer V2.0 prediction for F-actin-capping protein subunit beta isoforms 1 and… · a predicted model of the same protein · chain B against A, TM-score 0.97
- P13127 · AlphaFold monomer V2.0 prediction for F-actin-capping protein subunit alpha-1 (P13127) · a predicted model of the same protein · chain A against A, TM-score 0.95
- Q5VZK9 · AlphaFold monomer V2.0 prediction for F-actin-uncapping protein LRRC16A (Q5VZK9) · a predicted model of the same protein · chain T against A, TM-score 0.29
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13127
- Every structure of UniProt P14315
- Every structure of UniProt Q5VZK9
- Elsewhere: RCSB PDB 3LK2 · PDBe 3LK2 · UniProt P13127 · UniProt P14315 · UniProt Q5VZK9
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