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Crystal structure of the scan domain from human ZNF24

Analyse Crystal structure of the scan domain from human ZNF24 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3LHR
Type: protein
Length: 185 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Zinc finger protein 24
UniProt: P17028
Ligands: EMC, MG, CL
Pockets: 2 · best druggability 0.63

Structure

x-ray diffraction · 2 distinct chains · 75% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Zinc finger protein 24	protein	92	75% helix, 0% strand	P17028
B	Zinc finger protein 24	protein	93	75% helix, 0% strand	P17028

Ligands and binding sites

EMC · Ethyl mercury ion · ligand · 2 copies · chains A, B
MG · Magnesium ion · metal · chains A, B
CL · Chloride ion · ion · chains A
PEG · Di(hydroxyethyl)ether · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	100	0.63	0.88	21	empty
2	153	0.55	0.81	18	empty

Interfaces

1 interface between chains.

A–B · 1709 Å² buried · 23 hydrogen bonds · protein-protein

Compared structures

3LHR · Crystal structure of the SCAN domain from Human ZNF24 · the same entry in another collection · chain A against A, TM-score 1.00
P17028 · AlphaFold monomer V2.0 prediction for zinc finger protein 24 (P17028) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P17028
Elsewhere: RCSB PDB 3LHR · PDBe 3LHR · UniProt P17028

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