Research workbench

S-adenosylmethionine synthetase

Analyse S-adenosylmethionine synthetase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1FUG
Type: protein
Length: 766 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: S-adenosylmethionine synthetase
EC: 2.5.1.6
UniProt: P0A817
Pockets: 6 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 28% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	S-adenosylmethionine synthetase (EC 2.5.1.6)	protein	383	28% helix, 19% strand	P0A817

Pockets

6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	798	0.82	0.85	72	empty
2	811	0.79	0.83	80	empty
3	528	0.69	0.79	53	empty
4	82	0.53	0.85	18	empty
5	83	0.35	0.75	19	empty

Interfaces

1 interface between chains.

A–B · 2758 Å² buried · 34 hydrogen bonds · protein-protein

Compared structures

1FUG · S-adenosylmethionine synthetase · the same entry in another collection · chain A against A, TM-score 1.00
P0A817 · AlphaFold monomer V2.0 prediction for S-adenosylmethionine synthase (P0A817) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0A817
Elsewhere: RCSB PDB 1FUG · PDBe 1FUG · UniProt P0A817

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.