UniProt P0A817
S-adenosylmethionine synthetase (P0A817)
S-adenosylmethionine synthetase (UniProt P0A817), EC 2.5.1.6: 18 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 66 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P0A817
- Protein
- S-adenosylmethionine synthetase
- EC
- 2.5.1.6
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 66 · 5 records with a druggable one
Structures
19 records of P0A817 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1FUG | S-adenosylmethionine synthetase | x-ray diffraction | A, B | — | 6 (best 0.82) |
| 1FUG | S-adenosylmethionine synthetase | x-ray diffraction | A, B | — | — |
| 1MXA | S-adenosylmethionine synthetase with ppi | x-ray diffraction | A | PO4, MG, K, POP | — |
| 1MXA | S-adenosylmethionine synthetase with ppi | x-ray diffraction | A | — | — |
| 1MXB | S-adenosylmethionine synthetase with ADP | x-ray diffraction | A | PO4, MG, K, ADP | — |
| 1MXB | S-adenosylmethionine synthetase with ADP | x-ray diffraction | A | — | — |
| 1MXC | S-adenosylmethionine synthetase with 8-br-ADP | x-ray diffraction | A | PO4, MG, K, ABP | 1 (best 0.27) |
| 1MXC | S-adenosylmethionine synthetase with 8-br-ADP | x-ray diffraction | A | — | — |
| 1P7L | S-Adenosylmethionine synthetase complexed with AMPPNP and Met. | x-ray diffraction | A, B, C, D | K, MG, ANP, MET, SAM, PPK | 18 (best 0.84) |
| 1P7L | S-adenosylmethionine synthetase complexed with amppnp and met. | x-ray diffraction | A, B, C, D | — | — |
| 1RG9 | S-Adenosylmethionine synthetase complexed with SAM and PPNP | x-ray diffraction | A, B, C, D | K, MG, SAM, PPK | 20 (best 0.84) |
| 1RG9 | S-adenosylmethionine synthetase complexed with SAM and ppnp | x-ray diffraction | A, B, C, D | — | — |
| 1XRA | Crystal structure of S-adenosylmethionine synthetase | x-ray diffraction | A | PO4, MG, K | — |
| 1XRA | Crystal structure of S-adenosylmethionine synthetase | x-ray diffraction | A | — | — |
| 1XRC | Crystal structure of S-adenosylmethionine synthetase | x-ray diffraction | A | PO4, CO, K | — |
| 1XRC | Crystal structure of S-adenosylmethionine synthetase | x-ray diffraction | A | — | — |
| 8BB1 | T3 SAM lyase in complex with S-adenosylmethionine synthase | electron microscopy | A, B, C, D | — | 16 (best 0.83) |
| 8P4O | CryoEM structure of a GroEL7-GroES7 cage with encapsulated ordered substrate MetK in the presence… | electron microscopy | 1 | — | 5 (best 0.83) |
| P0A817 | AlphaFold monomer V2.0 prediction for S-adenosylmethionine synthase (P0A817) | predicted | A | — | — |
Ligands
- K · Potassium ion · in 7 records
- MG · Magnesium ion · in 6 records
- PO4 · Phosphate ion · in 5 records
- PPK · (diphosphono)aminophosphonic acid · in 2 records
- SAM · S-adenosylmethionine · in 2 records
- ABP · 8-bromoadenosine-5'-diphosphate · in 1 record
- ADP · Adenosine-5'-diphosphate · in 1 record
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 1 record
- CO · Cobalt (II) ion · in 1 record
- MET · Methionine · in 1 record
- POP · Pyrophosphate 2- · in 1 record
Experiment against prediction
- 1P7L chain C against the predicted model P0A817: TM-score 0.99, RMSD 0.80 Å
- 1RG9 chain C against the predicted model P0A817: TM-score 0.99, RMSD 0.80 Å
- 1P7L chain A against the predicted model P0A817: TM-score 0.99, RMSD 0.80 Å
- 1RG9 chain A against the predicted model P0A817: TM-score 0.99, RMSD 0.80 Å
- 1P7L chain B against the predicted model P0A817: TM-score 0.99, RMSD 0.80 Å
- 1P7L chain D against the predicted model P0A817: TM-score 0.99, RMSD 0.80 Å
- 1P7L chain D against the predicted model P0A817: TM-score 0.99, RMSD 0.80 Å
- 1RG9 chain B against the predicted model P0A817: TM-score 0.99, RMSD 0.80 Å
- 1RG9 chain D against the predicted model P0A817: TM-score 0.99, RMSD 0.80 Å
- 1RG9 chain D against the predicted model P0A817: TM-score 0.99, RMSD 0.80 Å
Elsewhere
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