Research workbench
Crystal complex of N-terminal human maltase-glucoamylase with kotalanol
Analyse Crystal complex of N-terminal human maltase-glucoamylase with kotalanol in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3L4V
- Type
- protein
- Length
- 863 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Maltase-glucoamylase, intestinal
- EC
- 3.2.1.20, 3.2.1.3
- UniProt
- O43451
- Ligands
- KTL, NAG
- Pockets
- 10 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 20% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Maltase-glucoamylase, intestinal (EC 3.2.1.20, 3.2.1.3) | protein | 863 | 20% helix, 31% strand | O43451 |
Ligands and binding sites
- KTL · (1S,2R,3R,4S)-1-{(1S)-2-[(2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium-1-yl]-1-hydroxyethyl}-2,3,4,5-tetrahydroxypentyl sulfate · ligand · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 5 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 54 | 0.71 | 0.99 | 19 | empty |
| 2 | 220 | 0.67 | 0.85 | 36 | empty |
| 3 | 121 | 0.48 | 0.79 | 21 | empty |
| 4 | 125 | 0.46 | 0.78 | 23 | empty |
| 5 | 75 | 0.45 | 0.81 | 17 | KTL |
Modifications
Observed in the structure: 3 glycan, 2 disulfide (N-glycosylation, disulfide).
Compared structures
- 3L4V · Crystal complex of N-terminal Human Maltase-Glucoamylase with kotalanol · the same entry in another collection · chain A against A, TM-score 1.00
- O43451 · AlphaFold monomer V2.0 prediction for maltase-glucoamylase, intestinal (O43451) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43451
- Elsewhere: RCSB PDB 3L4V · PDBe 3L4V · UniProt O43451
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