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Ligand · KTL

KTL · (1S,2R,3R,4S)-1-{(1S)-2-[(2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium-1-yl]-1-hydroxyethyl}-2,3,4,5-tetrahydroxypentyl sulfate

KTL, (1S,2R,3R,4S)-1-{(1S)-2-[(2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium-1-yl]-1-hydroxyethyl}-2,3,4,5-tetrahydroxypentyl sulfate (C12 H24 O12 S2, 424.4 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records…

Component
KTL
Formula
C12 H24 O12 S2
Class
ligand
Structures
4
PDB entries
2

Binding sites

KTL in 4 structures; the first of them:

  • 3L4V · Crystal complex of N-terminal Human Maltase-Glucoamylase with kotalanol · KTL A1001 · binds ASP203, THR204, TYR299, ASP327, ILE328, ILE364, TRP406, TRP441 and 7 more
  • 3LPP · Crystal complex of N-terminal sucrase-isomaltase with kotalanol · KTL B5001 · binds ASP231, GLN232, LEU233, TRP327, ASP355, ILE356, ILE392, TRP435 and 11 more
  • 3L4V · Crystal complex of N-terminal human maltase-glucoamylase with kotalanol · KTL A1001 · binds ASP203, THR204, TYR299, ASP327, ILE328, ILE364, TRP406, TRP441 and 7 more
  • 3LPP · Crystal complex of N-terminal sucrase-isomaltase with kotalanol · KTL B5001 · binds ASP231, GLN232, LEU233, TRP327, ASP355, ILE356, ILE392, TRP435 and 11 more

Residues it binds most

ASP 6, TRP 6, ILE 6, PHE 6, ARG 6, HIS 6, MET 6, GLN 4, LEU 4, LYS 4 (residue and the binding sites it lines).

Found with

  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • BMA · beta-D-mannopyranose
  • MAN · alpha-D-mannopyranose
  • CL · Chloride ion
  • PEG · Di(hydroxyethyl)ether
  • TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol

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