Research workbench

Crystal structure of E. COLI HPPK(H115A)

Analyse Crystal structure of E. COLI HPPK(H115A) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3KUG
Type: protein
Length: 158 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EC: 2.7.6.3
UniProt: P26281
Pockets: 2 · best druggability 0.37

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3)	protein	158	31% helix, 27% strand	P26281

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	66	0.37	0.78	20	empty
2	70	0.32	0.75	14	empty

Compared structures

3KUG · Crystal structure of E. coli HPPK(H115A) · the same entry in another collection · chain A against A, TM-score 1.00
P26281 · AlphaFold monomer V2.0 prediction for 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine… · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P26281
Elsewhere: RCSB PDB 3KUG · PDBe 3KUG · UniProt P26281

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.