UniProt P26281
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (P26281)
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (UniProt P26281), EC 2.7.6.3: 116 experimental structures and 1 predicted model on GenesisL1, 16 ligands bound, 11 pockets. Binding sites, druggability and…
- UniProt
- P26281
- Protein
- 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
- EC
- 2.7.6.3
- Experimental structures
- 116
- Predicted models
- 1
- Ligands
- 16
- Pockets
- 11 · 4 records with a druggable one
Structures
117 records of P26281 in the MolNFT archive: 116 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DY3 | Ternary complex of 7,8-dihydro-6-hydroxymethylpterinpyrophosphokinase from Escherichia coli with… | x-ray diffraction | A | — | — |
| 1DY3 | Ternary complex of 7,8-dihydro-6-hydroxymethylpterinpyrophosphokinase from escherichia COLI with… | x-ray diffraction | A | — | — |
| 1EQ0 | Solution structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase complexed with mgamppcp | solution nmr | A | — | — |
| 1EQ0 | Solution structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase complexed with mgamppcp | solution nmr | A | — | — |
| 1EQM | Crystal structure of binary complex of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase with… | x-ray diffraction | A | — | — |
| 1EQM | Crystal structure of binary complex of 6-hydroxymethyl-7,8- dihydropterin pyrophosphokinase with… | x-ray diffraction | A | — | — |
| 1EX8 | Crystal structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase complexed with HP4A, the… | x-ray diffraction | A | — | — |
| 1EX8 | Crystal structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase complexed with HP4A, the… | x-ray diffraction | A | — | — |
| 1F9H | Crystal structure of the ternary complex of E. COLI HPPK(R92A) with mgampcpp and… | x-ray diffraction | A | — | — |
| 1F9H | Crystal structure of the ternary complex of E. COLI HPPK(R92A) with mgampcpp and… | x-ray diffraction | A | — | — |
| 1G4C | Crystal structure of a complex of HPPK(R92A) from E.COLI with MG2+ at 1.65 ångström resolution | x-ray diffraction | A, B | — | — |
| 1G4C | Crystal structure of a complex of HPPK(R92A) from E.COLI with MG2+ at 1.65 ångström resolution | x-ray diffraction | A, B | — | — |
| 1HKA | 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase | x-ray diffraction | A | — | — |
| 1HKA | 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase | x-ray diffraction | A | — | — |
| 1HQ2 | Crystal structure of a ternary complex of E.COLI HPPK(R82A) with mgampcpp and… | x-ray diffraction | A | — | — |
| 1HQ2 | Crystal structure of a ternary complex of E.COLI HPPK(R82A) with mgampcpp and… | x-ray diffraction | A | — | — |
| 1IM6 | Crystal structure of unligated HPPK(R82A) from E.COLI at 1.74 ångström resolution | x-ray diffraction | A | — | — |
| 1IM6 | Crystal structure of unligated HPPK(R82A) from E.COLI at 1.74 ångström resolution | x-ray diffraction | A | — | — |
| 1KBR | Crystal structure of unligated HPPK(R92A) from E.COLI at 1.55 ångström resolution | x-ray diffraction | A | — | — |
| 1KBR | Crystal structure of unligated HPPK(R92A) from E.COLI at 1.55 ångström resolution | x-ray diffraction | A | — | — |
| 1Q0N | Crystal structure of a ternary complex of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from… | x-ray diffraction | A | — | — |
| 1Q0N | Crystal structure of a ternary complex of 6-hydroxymethyl-7, 8-dihydropterin pyrophosphokinase from… | x-ray diffraction | A | — | — |
| 1RAO | Crystal structure of a ternary complex of E. COLI hppk with AMP and… | x-ray diffraction | A | — | — |
| 1RAO | Crystal structure of a ternary complex of E. COLI hppk with AMP and… | x-ray diffraction | A | — | — |
| 1RB0 | Crystal structure of a binary complex of E. COLI hppk with 6-hydroxymethylpterin-diphosphate at… | x-ray diffraction | A | — | — |
| 1RB0 | Crystal structure of a binary complex of E. COLI hppk with 6-hydroxymethylpterin-diphosphate at… | x-ray diffraction | A | — | — |
| 1RTZ | Crystal structure of E.COLI apo-HPPK(V83G/DEL84-89) at 1.33 ångström resolution | x-ray diffraction | A | — | — |
| 1RTZ | Crystal structure of E.COLI apo-HPPK(V83G/DEL84-89) at 1.33 ångström resolution | x-ray diffraction | A | — | — |
| 1RU1 | Crystal structure of a ternary complex of E. COLI HPPK(V83G/DEL84-89) with mgampcpp and… | x-ray diffraction | A, B | — | — |
| 1RU1 | Crystal structure of a ternary complex of E. COLI HPPK(V83G/DEL84-89) with mgampcpp and… | x-ray diffraction | A, B | — | — |
| 1RU2 | Crystal structure of a ternary complex of E.COLI HPPK(V83G/DEL84-89) with mgampcpp and… | x-ray diffraction | A | — | — |
| 1RU2 | Crystal structure of a ternary complex of E.COLI HPPK(V83G/DEL84-89) with mgampcpp and… | x-ray diffraction | A | — | — |
| 1TMJ | Crystal structure of E.coli apo-HPPK(W89A) at 1.45 Angstrom resolution | x-ray diffraction | A | — | — |
| 1TMJ | Crystal structure of E.COLI apo-HPPK(W89A) at 1.45 ångström resolution | x-ray diffraction | A | — | — |
| 1TMM | Crystal structure of ternary complex of E.coli HPPK(W89A) with MGAMPCPP and 6-Hydroxymethylpterin | x-ray diffraction | A, B | — | — |
| 1TMM | Crystal structure of ternary complex of E.COLI HPPK(W89A) with mgampcpp and 6-hydroxymethylpterin | x-ray diffraction | A, B | — | — |
| 2F63 | Solution structure of HPPK in complex with inhibitor analogs AMPCPP and HP-1 | solution nmr | A | — | — |
| 2F63 | Solution structure of hppk in complex with inhibitor analogs ampcpp and hp-1 | solution nmr | A | — | — |
| 2F65 | Solution structure of HPPK in complex with inhibitor analog AMPCPP | solution nmr | A | — | — |
| 2F65 | Solution structure of hppk in complex with inhibitor analog ampcpp | solution nmr | A | — | — |
| 3HCX | Crystal structure of E. coli HPPK(N10A) | x-ray diffraction | A | — | — |
| 3HCX | Crystal structure of E. COLI HPPK(N10A) | x-ray diffraction | A | — | — |
| 3HD1 | Crystal structure of E. coli HPPK(N10A) in complex with MgAMPCPP | x-ray diffraction | A | — | — |
| 3HD1 | Crystal structure of E. COLI HPPK(N10A) in complex with mgampcpp | x-ray diffraction | A | — | — |
| 3HD2 | Crystal structure of E. coli HPPK(Q50A) in complex with MgAMPCPP and pterin | x-ray diffraction | A | — | — |
| 3HD2 | Crystal structure of E. COLI HPPK(Q50A) in complex with mgampcpp and pterin | x-ray diffraction | A | — | — |
| 3HSD | Crystal structure of E. coli HPPK(Y53A) | x-ray diffraction | A, B | — | — |
| 3HSD | Crystal structure of E. COLI HPPK(Y53A) | x-ray diffraction | A, B | — | — |
| 3HSG | Crystal structure of E. coli HPPK(Y53A) in complex with MgAMPCPP | x-ray diffraction | A | — | — |
| 3HSG | Crystal structure of E. COLI HPPK(Y53A) in complex with mgampcpp | x-ray diffraction | A | — | — |
| 3HSJ | Crystal structure of E. coli HPPK(N55A) | x-ray diffraction | A | — | — |
| 3HSJ | Crystal structure of E. COLI HPPK(N55A) | x-ray diffraction | A | — | — |
| 3HSZ | Crystal structure of E. coli HPPK(F123A) | x-ray diffraction | A | — | — |
| 3HSZ | Crystal structure of E. COLI HPPK(F123A) | x-ray diffraction | A | — | — |
| 3HT0 | Crystal structure of E. coli HPPK(F123A) in complex with MgAMPCPP | x-ray diffraction | A | — | — |
| 3HT0 | Crystal structure of E. COLI HPPK(F123A) in complex with mgampcpp | x-ray diffraction | A | — | — |
| 3ILI | Crystal structure of E. coli HPPK(D95A) | x-ray diffraction | A | — | — |
| 3ILI | Crystal structure of E. COLI HPPK(D95A) | x-ray diffraction | A | — | — |
| 3ILJ | Crystal structure of E. coli HPPK(D95A) in complex with MgAMPCPP | x-ray diffraction | A | — | — |
| 3ILJ | Crystal structure of E. COLI HPPK(D95A) in complex with mgampcpp | x-ray diffraction | A | — | — |
57 records more on the page itself.
Ligands
- CL · Chloride ion · in 8 records
- CA · Calcium ion · in 6 records
- APC · Diphosphomethylphosphonic acid adenosyl ester · in 4 records
- NA · Sodium ion · in 4 records
- ATP · Adenosine-5'-triphosphate · in 2 records
- H73 · 5'-S-[(2R,4R)-1-{2-[(2-amino-7,7-dimethyl-4-oxo-3,4,7, 8-tetrahydropteridine-6-carbonyl)amino]ethyl}-2-carboxypiperidin-4-yl]-5'-thioadenosine · in 2 records
- J1F · ((2-(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carboxamido)-N-(2-((((2R,3S,4R, 5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)amino)-2-oxoethyl)acetamido)methyl)phosphonic acid · in 2 records
- J1L · 5'-{[(2R,4R)-1-{2-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carbonyl)amino]ethyl}-2-carboxypiperidin-4-yl]sulfonyl}-5'-deoxyadenosine · in 2 records
- 5RU · 2-azanyl-8-[(2-fluorophenyl)methylsulfanyl]-1,9-dihydropurin-6-one · in 1 record
- 5RV · 2-[(2-azanyl-6-oxidanylidene-3,9-dihydropurin-8-yl)sulfanylmethyl]benzenecarbonitrile · in 1 record
- 5RW · 2-azanyl-8-[(4-fluorophenyl)methylsulfanyl]-1,7-dihydropurin-6-one · in 1 record
- 5RX · 2-azanyl-8-[(4-chlorophenyl)methylsulfanyl]-1,9-dihydropurin-6-one · in 1 record
- 5RY · 4-[(2-azanyl-6-oxidanylidene-1,9-dihydropurin-8-yl)sulfanylmethyl]-3-fluoranyl-benzenecarbonitrile · in 1 record
- 5RZ · 2-azanyl-8-[2-(4-bromophenyl)-2-oxidanylidene-ethyl]sulfanyl-1,9-dihydropurin-6-one · in 1 record
- J1I · 5'-S-{2-[{2-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carbonyl) amino]ethyl}(phosphonomethyl)amino]ethyl}-5'-thioadenosine · in 1 record
- ZX4 · 5'-S-{(2R,4R)-1-[3-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]-2-carboxypiperidin-4-yl}-5'-thioadenosine · in 1 record
Experiment against prediction
- 3KUH chain A against the predicted model P26281: TM-score 0.99, RMSD 0.45 Å
- 3KUH chain A against the predicted model P26281: TM-score 0.99, RMSD 0.45 Å
- 3ILO chain A against the predicted model P26281: TM-score 0.99, RMSD 0.46 Å
- 3ILO chain A against the predicted model P26281: TM-score 0.99, RMSD 0.46 Å
- 3IP0 chain A against the predicted model P26281: TM-score 0.99, RMSD 0.49 Å
- 3IP0 chain A against the predicted model P26281: TM-score 0.99, RMSD 0.49 Å
- 1HQ2 chain A against the predicted model P26281: TM-score 0.99, RMSD 0.51 Å
- 1HQ2 chain A against the predicted model P26281: TM-score 0.99, RMSD 0.51 Å
- 1Q0N chain A against the predicted model P26281: TM-score 0.99, RMSD 0.53 Å
- 1Q0N chain A against the predicted model P26281: TM-score 0.99, RMSD 0.53 Å
Elsewhere
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