H73 · 5'-S-[(2R,4R)-1-{2-[(2-amino-7,7-dimethyl-4-oxo-3,4,7, 8-tetrahydropteridine-6-carbonyl)amino]ethyl}-2-carboxypiperidin-4-yl]-5'-thioadenosine

Binding sites

H73 in 4 structures; the first of them:

• 7KDO · Crystal structure of Escherichia coli HPPK in complex with bisubstrate inhibitor HP-73 · H73 A201 · binds GLY8, THR42, PRO43, PRO44, LEU45, TYR53, ASN55, LEU70 and 18 more
• 8SK1 · Bacillus anthracis HPPK in complex with bisubstrate inhibitor HP-73 · H73 A201 · binds GLY10, THR44, GLU45, PRO46, VAL47, GLN52, PHE55, ASN57 and 19 more
• 8SL9 · Crystal structure of Francisella tularensis HPPK-DHPS in complex with HPPK inhibitor HP-73 · H73 A501 · binds GLY8, SER42, LYS43, ALA44, VAL45, PHE58, ASN60, LEU75 and 15 more
• 7KDO · Crystal structure of escherichia COLI hppk in complex with bisubstrate inhibitor hp-73 · H73 A201 · binds THR42, PRO43, PRO44, LEU45, TYR53, ASN55, LEU70, GLN74 and 16 more

Residues it binds most

ARG 5, LEU 5, ASP 5, ILE 5, PHE 5, ASN 5, THR 5, TRP 5, VAL 5, GLN 4 (residue and the binding sites it lines).

Found with

• CL · Chloride ion
• EDO · 1,2-ethanediol