Structural basis of ataxin-2 recognition by POLY(A)-binding protein

Structure

x-ray diffraction · 2 distinct chains · 66% helix, 0% strand (DSSP).

Ligands and binding sites

• CD · Cadmium ion · metal · chains A
• SO4 · Sulfate ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 766 Ų buried · 14 hydrogen bonds · protein-protein

Compared structures

• 3KTR · Structural basis of ataxin-2 recognition by poly(A)-binding protein · the same entry in another collection · chain A against A, TM-score 1.00
• P11940 · AlphaFold monomer V2.0 prediction for polyadenylate-binding protein 1 (P11940) · a predicted model of the same protein · chain A against A, TM-score 0.97
• Q99700 · AlphaFold monomer V2.0 prediction for ataxin-2 (Q99700) · a predicted model of the same protein · chain B against A, TM-score 0.25

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P11940
• Every structure of UniProt Q99700
• Elsewhere: RCSB PDB 3KTR · PDBe 3KTR · UniProt P11940 · UniProt Q99700