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Crystal structure of the histone domain, dh-pH unit, and catalytic unit of the RAS activator son of sevenless (sos)

Analyse Crystal structure of the histone domain, dh-pH unit, and catalytic unit of the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3KSY
Type: protein
Length: 1,007 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Son of sevenless homolog 1
UniProt: Q07889
Pockets: 19 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 56% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Son of sevenless homolog 1	protein	1007	56% helix, 5% strand	Q07889

Pockets

19 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	795	0.82	0.84	93	empty
2	768	0.68	0.75	75	empty
3	349	0.65	0.80	32	empty
4	242	0.54	0.77	32	empty
5	172	0.54	0.80	18	empty

Compared structures

3KSY · Crystal structure of the Histone domain, DH-PH unit, and catalytic unit of the Ras… · the same entry in another collection · chain A against A, TM-score 1.00
Q07889 · AlphaFold monomer V2.0 prediction for son of sevenless homolog 1 (Q07889) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q07889
Elsewhere: RCSB PDB 3KSY · PDBe 3KSY · UniProt Q07889

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