Research workbench
Enhancing the therapeutic properties of a protein by a designed zinc- binding site, structural principles of a novel long-acting insulin analog
Analyse Enhancing the therapeutic properties of a protein by a designed zinc- binding… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3KQ6
- Type
- protein
- Length
- 102 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin a chain; Insulin B chain
- UniProt
- P01308
- Ligands
- IPH, ZN, CL
Structure
x-ray diffraction · 2 distinct chains · 51% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Insulin a chain | protein | 21 | 57% helix, 5% strand | P01308 |
| B, D | Insulin B chain | protein | 30 | 47% helix, 10% strand | P01308 |
Ligands and binding sites
- IPH · Phenol · ligand · chains C, D
- ZN · Zinc ion · metal · 3 copies · chains A, B, D
- CL · Chloride ion · ion · 2 copies · chains A, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
5 interfaces between chains.
- A–B · 776 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 659 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 603 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 62 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 28 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 3KQ6 · Enhancing the Therapeutic Properties of a Protein by a Designed Zinc-Binding Site… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 3KQ6 · PDBe 3KQ6 · UniProt P01308
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