Research workbench
Mcl-1 in complex with bim BH3 mutant I2DA
Analyse Mcl-1 in complex with bim BH3 mutant I2DA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3KJ1
- Type
- protein
- Length
- 174 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Induced myeloid leukemia cell differentiation protein mcl- 1; BCL-2-like protein 11
- UniProt
- Q07820, O43521
- Ligands
- ZN, CL
Structure
x-ray diffraction · 2 distinct chains · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Induced myeloid leukemia cell differentiation protein mcl- 1 | protein | 152 | 72% helix, 0% strand | Q07820 |
| B | BCL-2-like protein 11 | protein | 22 | 91% helix, 0% strand | O43521 |
Ligands and binding sites
- ZN · Zinc ion · metal · 5 copies · chains A, B
- CL · Chloride ion · ion · chains A
- ACT · Acetate ion · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 1051 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 3KJ1 · Mcl-1 in complex with Bim BH3 mutant I2dA · the same entry in another collection · chain A against A, TM-score 1.00
- Q07820 · AlphaFold monomer V2.0 prediction for induced myeloid leukemia cell differentiation… · a predicted model of the same protein · chain A against A, TM-score 0.95
- O43521 · AlphaFold monomer V2.0 prediction for BCL-2-like protein 11 (O43521) · a predicted model of the same protein · chain B against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07820
- Every structure of UniProt O43521
- Elsewhere: RCSB PDB 3KJ1 · PDBe 3KJ1 · UniProt Q07820 · UniProt O43521
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