Research workbench

SGF11:SUS1 complex

Analyse SGF11:SUS1 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3KIK
Type: protein
Length: 481 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein SUS1; Saga-associated factor 11
UniProt: Q6WNK7, Q03067
Pockets: 3 · best druggability 0.43

Structure

x-ray diffraction · 7 distinct chains · 83% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein SUS1	protein	94	80% helix, 0% strand	Q6WNK7
E, F	Saga-associated factor 11	protein	27	85% helix, 0% strand	Q03067
B	Protein SUS1	protein	92	86% helix, 0% strand	Q6WNK7
C	Protein SUS1	protein	93	86% helix, 0% strand	Q6WNK7
G	Saga-associated factor 11	protein	28	89% helix, 0% strand	Q03067
D	Protein SUS1	protein	92	79% helix, 0% strand	Q6WNK7
H	Saga-associated factor 11	protein	28	82% helix, 0% strand	Q03067

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	135	0.43	0.76	23	empty
2	135	0.41	0.75	22	empty
3	60	0.33	0.76	16	empty

Interfaces

17 interfaces between chains.

C–G · 1292 Å² buried · 2 hydrogen bonds · protein-protein
B–F · 1278 Å² buried · 4 hydrogen bonds · protein-protein
A–E · 1154 Å² buried · 2 hydrogen bonds · protein-protein
D–H · 1107 Å² buried · 0 hydrogen bonds · protein-protein
B–C · 525 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

3KIK · Sgf11:Sus1 complex · the same entry in another collection · chain H against H, TM-score 1.00
Q6WNK7 · AlphaFold monomer V2.0 prediction for transcription and mRNA export factor SUS1 (Q6WNK7) · a predicted model of the same protein · chain B against A, TM-score 0.93
Q03067 · AlphaFold monomer V2.0 prediction for saga-associated factor 11 (Q03067) · a predicted model of the same protein · chain H against A, TM-score 0.78

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6WNK7
Every structure of UniProt Q03067
Elsewhere: RCSB PDB 3KIK · PDBe 3KIK · UniProt Q6WNK7 · UniProt Q03067

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