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Crystal structure of the SH3-kinase fragment of tight junction protein 3 (TJP3) in apo-form
Analyse Crystal structure of the SH3-kinase fragment of tight junction protein 3 (TJP3)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3KFV
- Type
- protein
- Length
- 241 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tight junction protein zo-3
- UniProt
- O95049
- Ligands
- UNX
- Pockets
- 3 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tight junction protein zo-3 | protein | 241 | 38% helix, 26% strand | O95049 |
Ligands and binding sites
- UNX · Unknown atom or ion · ion · 10 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 370 | 0.69 | 0.82 | 33 | UNX |
| 2 | 50 | 0.41 | 0.82 | 11 | empty |
| 3 | 54 | 0.28 | 0.74 | 17 | empty |
Modifications
Observed in the structure: 3 modified (engineered).
Compared structures
- 3KFV · Crystal structure of the SH3-kinase fragment of tight junction protein 3 (TJP3) in… · the same entry in another collection · chain A against A, TM-score 1.00
- O95049 · AlphaFold monomer V2.0 prediction for tight junction protein zo-3 (O95049) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95049
- Elsewhere: RCSB PDB 3KFV · PDBe 3KFV · UniProt O95049
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