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Human mdmx liganded with a 12MER peptide inhibitor (PDI6W)

Analyse Human mdmx liganded with a 12MER peptide inhibitor (PDI6W) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3JZP
Type: protein
Length: 99 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein MDM4; PDI6W peptide (12MER)
UniProt: O15151
Ligands: K

Structure

x-ray diffraction · 2 distinct chains · 45% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein MDM4	protein	87	45% helix, 17% strand	O15151
P	PDI6W peptide (12MER)	protein	12	50% helix, 0% strand	—

Ligands and binding sites

K · Potassium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–P · 574 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

3JZP · Human MDMX liganded with a 12mer peptide inhibitor (pDI6W) · the same entry in another collection · chain A against A, TM-score 1.00
O15151 · AlphaFold monomer V2.0 prediction for protein MDM4 (O15151) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O15151
Elsewhere: RCSB PDB 3JZP · PDBe 3JZP · UniProt O15151

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